kb NB 142-70

• Supplier: Tocris Bioscience
• Catalog: 4513
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1233533-04-4
• Chemical Name: 9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one
• Formula: C11H9NO2S2
• Molecular Weight: 251.32
• Purity: >98 %
• Description: Selective protein kinase D (PKD) inhibitor (IC 50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro ; displays prominent cytotoxic and anti-proliferative effects.

Product References

Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell - Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell

Lavalle CR, Bravo-Altamirano K, Giridhar KV, Chen J, Sharlow E, Lazo JS, Wipf P, Wang QJ. BMC Chem Biol. 2010 May 5;10:5.

Synthesis and Structure-Activity Relationships of Benzothienothiazepinone - Synthesis and Structure-Activity Relationships of Benzothienothiazepinone

Bravo-Altamirano K, George KM, Frantz MC, Lavalle CR, Tandon M, Leimgruber S, Sharlow ER, Lazo JS, Wang QJ, Wipf P. ACS Med Chem Lett. 2011 Feb 14;2(2):154-159.

PKD1 mediates negative feedback of PI3K/Akt activation in response to G - PKD1 mediates negative feedback of PI3K/Akt activation in response to G

Ni Y, Sinnett-Smith J, Young SH, Rozengurt E. PLoS One. 2013 Sep 9;8(9):e73149.