KB-R7943 mesylate

• Supplier: Tocris Bioscience
• Catalog: 4660
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 182004-65-5
• Chemical Name: 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate
• Formula: C16H17N3O3S.CH3SO3H
• Molecular Weight: 427.49
• Purity: >99 %
• Description: Potent, selective inhibitor of the reverse mode of the Na + /Ca 2+ exchanger (IC 50 = 0.7 μ M). Also inhibits the mitochondrial Ca 2+ uniporter (MCU; IC 50 = 5.5 μ M). Does not affect Na + -dependent transport systems or ionotropic glutamate receptors.

Product References

Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ - Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+

Hoyt KR, Arden SR, Aizenman E, Reynolds IJ. Mol Pharmacol. 1998 Apr;53(4):742-9.

The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat - The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat

Schroder UH, Breder J, Sabelhaus CF, Reymann KG. Neuropharmacology. 1999 Feb;38(2):319-21.

Effect of Na+/Ca2+ exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in - Effect of Na+/Ca2+ exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in

Watano T, Harada Y, Harada K, Nishimura N. Br J Pharmacol. 1999 Aug;127(8):1846-50.

The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent - The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent

Santo-Domingo J, Vay L, Hernandez-Sanmiguel E, Lobaton CD, Moreno A, Montero M, Alvarez J. Br J Pharmacol. 2007 Jul;151(5):647-54. Epub 2007 Apr 30.