KC 12291 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1244
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 181936-98-1
• Chemical Name: 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanaminehydrochloride
• Formula: C22H27N3O3S.HCl
• Molecular Weight: 449.99
• Purity: >97 %
• Description: Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (I NaL ) and prevents diastolic contracture in isolated atria in vitro (IC 50 values are 9.6 and 0.55 - 0.79 μ M respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo .

Product References

Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria - Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria

Tamareille S, Le Grand B, John GW, Feuvray D, Coulombe A. J Cardiovasc Pharmacol. 2002 Sep;40(3):346-55.

KC 12291: an atypical sodium channel blocker with myocardial antiischemic - KC 12291: an atypical sodium channel blocker with myocardial antiischemic

John GW, Letienne R, Le Grand B, Pignier C, Vacher B, Patoiseau JF, Colpaert FC, Coulombe A. Cardiovasc Drug Rev. 2004 Spring;22(1):17-26.

Pharmacological characterisation of sodium channels in sinoatrial node pacemaking - Pharmacological characterisation of sodium channels in sinoatrial node pacemaking

Letienne R, Vie B, Le Grand B. Eur J Pharmacol. 2006 Jan 20;530(3):243-9. Epub 2005 Dec 20.