KC7F2

• Supplier: Tocris Bioscience
• Catalog: 3251
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 927822-86-4
• Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
• Formula: C16H16Cl4N2O4S4
• Molecular Weight: 570.38
• Purity: >98 %
• Description: Inhibitor of HIF-1 α . Thought to act via down-regulation of HIF-1 α protein synthesis; reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Also blocks hypoxia-induced HIF-1 α accumulation in a range of human cancer cell lines. Inhibits the expression of HIF target genes, such as carbonic anhydrase IX and MMP2.

Product References

Inhibiting the hypoxia response for cancer therapy: the new kid on the block. - Inhibiting the hypoxia response for cancer therapy: the new kid on the block.

Koh MY, Spivak-Kroizman TR, Powis G. Clin Cancer Res. 2009 Oct 1;15(19):5945-6.

Identification of a novel small molecule HIF-1alpha translation inhibitor. - Identification of a novel small molecule HIF-1alpha translation inhibitor.

Narita T, Yin S, Gelin CF, Moreno CS, Yepes M, Nicolaou KC, Van Meir EG. Clin Cancer Res. 2009 Oct 1;15(19):6128-36.