Kenpaullone

Name Kenpaullone
Supplier Tocris Bioscience
Catalog 4324
Prices $175.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 142273-20-9
Chemical Name 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one
Formula C16H11BrN2O
Molecular Weight 327.18
Purity >98 %
Description Potent inhibitor of CDK1/cyclin B and GSK-3 β (IC 50 values are 0.4 and 0.23 μ M respectively). Also inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC 50 values are 0.68, 7.5 and 0.85 μ M respectively). Selective over c-src (IC 50 = 15 μ M), casein kinase 2 (IC 50 = 20 μ M), ERK1 (IC 50 = 20 μ M), ERK2 (IC 50 = 9 μ M) and a range of other protein kinases (IC 50 values > 35 μ M). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.
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