Name | Kenpaullone |
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Supplier | Tocris Bioscience |
Catalog | 4324 |
Prices | $175.00 |
Sizes | 10 mg |
Function Type | Inhibitor |
Cas Number | 142273-20-9 |
Chemical Name | 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one |
Formula | C16H11BrN2O |
Molecular Weight | 327.18 |
Purity | >98 % |
Description | Potent inhibitor of CDK1/cyclin B and GSK-3 β (IC 50 values are 0.4 and 0.23 μ M respectively). Also inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC 50 values are 0.68, 7.5 and 0.85 μ M respectively). Selective over c-src (IC 50 = 15 μ M), casein kinase 2 (IC 50 = 20 μ M), ERK1 (IC 50 = 20 μ M), ERK2 (IC 50 = 9 μ M) and a range of other protein kinases (IC 50 values > 35 μ M). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4. |
Supplier Page | Shop |
Feng R, Ma H, Hassig CA, Payne JE, Smith ND, Mapara MY, Hager JH, Lentzsch S. Mol Cancer Ther. 2008 Jun;7(6):1494-505.
Hassig CA, Symons KT, Guo X, Nguyen PM, Annable T, Wash PL, Payne JE, Jenkins DA, Bonnefous C, Trotter C, Wang Y, Anzola JV, Milkova EL, Hoffman TZ, Dozier SJ, Wiley BM, Saven A, Malecha JW, Davis RL, Muhammad J, Shiau AK, Noble SA, Rao TS, Smith ND, Hager JH. Mol Cancer Ther. 2008 May;7(5):1054-65.
Payne JE, Bonnefous C, Hassig CA, Symons KT, Guo X, Nguyen PM, Annable T, Wash PL, Hoffman TZ, Rao TS, Shiau AK, Malecha JW, Noble SA, Hager JH, Smith ND. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6093-6.