Ki 16425

• Supplier: Tocris Bioscience
• Catalog: 4888
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 355025-24-0
• Chemical Name: 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]propanoicacid
• Formula: C23H23ClN2O5S
• Molecular Weight: 474.96
• Purity: >98 %
• Description: Antagonist of the lysophosphatidic acid receptors LPA 1 and LPA 3 (K i values are 0.25 and 0.36 μ M respectively, in a GTP γ S binding assay). Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway, in HEK293A cells.

Product References

Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid - Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid

Ohta H, Sato K, Murata N, Damirin A, Malchinkhuu E, Kon J, Kimura T, Tobo M, Yamazaki Y, Watanabe T, Yagi M, Sato M, Suzuki R, Murooka H, Sakai T, Nishitoba T, Im DS, Nochi H, Tamoto K, Tomura H, Okajima F. Mol Pharmacol. 2003 Oct;64(4):994-1005.

Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human - Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human

Yamada T, Sato K, Komachi M, Malchinkhuu E, Tobo M, Kimura T, Kuwabara A, Yanagita Y, Ikeya T, Tanahashi Y, Ogawa T, Ohwada S, Morishita Y, Ohta H, Im DS, Tamoto K, Tomura H, Okajima F. J Biol Chem. 2004 Feb 20;279(8):6595-605. Epub 2003 Dec 3.

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. - Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.

Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL. Cell. 2012 Aug 17;150(4):780-91.