Ki 20227

• Supplier: Tocris Bioscience
• Catalog: 5056
• Prices: $255.00, $1,045.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 623142-96-1
• Chemical Name: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea
• Formula: C24H24N4O5S
• Molecular Weight: 480.54
• Purity: >97 %
• Description: Inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC 50 values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses osteoclast differentiation and osteolysis in a rat bone metastasis model.

Product References

A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation - A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation

Ohno H, Kubo K, Murooka H, Kobayashi Y, Nishitoba T, Shibuya M, Yoneda T, Isoe T. Mol Cancer Ther. 2006 Nov;5(11):2634-43.

The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits - The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits

Ohno H, Uemura Y, Murooka H, Takanashi H, Tokieda T, Ohzeki Y, Kubo K, Serizawa I. Eur J Immunol. 2008 Jan;38(1):283-91.

M-CSF inhibition selectively targets pathological angiogenesis and - M-CSF inhibition selectively targets pathological angiogenesis and

Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H, Suda T. J Exp Med. 2009 May 11;206(5):1089-102.