KML 29

• Supplier: Tocris Bioscience
• Catalog: 3143
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1380424-42-9
• Chemical Name: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylicacid2,2,2-trifluoro-1-(trifluoromethyl)ethylester
• Formula: C24H21F6NO7
• Molecular Weight: 549.42
• Purity: >98 %
• Description: Highly selective and potent monoacylglycerol lipase (MAGL) inhibitor. Exhibits potent inhibition of human, mouse and rat MAGL (IC 50 values are 5.9, 15 and 43 nM, respectively). Exhibits no detectable inhibition of FAAH (IC 50 > 50000 nM). Potently and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC 50 = 2.5 nM and >50 μ M for 2-AG and AEA respectively).

Product References

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group - Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group

Chang JW, Niphakis MJ, Lum KM, Cognetta AB 3rd, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH, Cravatt BF. Chem Biol. 2012 May 25;19(5):579-88.

Discrimination between two endocannabinoids. - Discrimination between two endocannabinoids.

Ueda N, Tsuboi K. Chem Biol. 2012 May 25;19(5):545-7.