KN-62

• Supplier: Tocris Bioscience
• Catalog: 5215
• Prices: $139.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 127191-97-3
• Chemical Name: 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenylisoquinolinesulfonicacidester
• Formula: C38H35N5O6S2
• Molecular Weight: 721.84
• Purity: >98 %
• Description: Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM).

Product References

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi - KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi

Tokumitsu H, Chijiwa T, Hagiwara M, Mizutani A, Terasawa M, Hidaka H. J Biol Chem. 1990 Mar 15;265(8):4315-20.

Molecular and cellular pharmacology of a calcium/calmodulin-dependent protein - Molecular and cellular pharmacology of a calcium/calmodulin-dependent protein

Hidaka H, Yokokura H. Adv Pharmacol. 1996;36:193-219.

Effects of antagonists at the human recombinant P2X7 receptor. - Effects of antagonists at the human recombinant P2X7 receptor.

Chessell IP, Michel AD, Humphrey PP. Br J Pharmacol. 1998 Jul;124(6):1314-20.