Ko 143

• Supplier: Tocris Bioscience
• Catalog: 1278
• Prices: $115.00, $249.00
• Sizes: 1 mg, 10 mg
• Function Type: Inhibitor
• Cas Number: 461054-93-3
• Chemical Name: (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoicacid1,1-dimethylethylester
• Formula: C26H35N3O5
• Molecular Weight: 469.57
• Purity: >99 %
• Description: Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC 90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance. Inhibits ABCB1 and ABCC1 at higher concentrations. Rapidly metabolized in rat plasma.

Product References

Potent and specific inhibition of the breast cancer resistance protein multidrug - Potent and specific inhibition of the breast cancer resistance protein multidrug

Allen JD, van Loevezijn A, Lakhai JM, van der Valk M, van Tellingen O, Reid G, Schellens JH, Koomen GJ, Schinkel AH. Mol Cancer Ther. 2002 Apr;1(6):417-25.

Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide - Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide

Allen JD, Van Dort SC, Buitelaar M, van Tellingen O, Schinkel AH. Cancer Res. 2003 Mar 15;63(6):1339-44.