Kobe 0065

• Supplier: Tocris Bioscience
• Catalog: 3241
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 436133-68-5
• Chemical Name: N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
• Formula: C15H11ClF3N5O4S
• Molecular Weight: 449.79
• Description: H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.

Product References

Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines - Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines

Park CH, Choe H, Jang IY, Kwon SY, Latif M, Lee HK, Lee HJ, Yang EH, Yun JI, Chae CH, Cho SY, Choi SU, Ha JD, Jung H, Kim HR, Kim P, Lee CO, Yun CS, Lee K. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6192-6.

ALK inhibitors of bis-ortho-alkoxy-para-piperazinesubstituted-pyrimidines and - ALK inhibitors of bis-ortho-alkoxy-para-piperazinesubstituted-pyrimidines and

Lee HJ, Latif M, Choe H, Ali I, Lee HK, Yang EH, Yun JI, Chae CH, Jung JK, Kim HR, Lee CO, Park CH, Lee K. Arch Pharm Res. 2014;37(9):1130-8.