KRIBB11

• Supplier: Tocris Bioscience
• Catalog: 5098
• Prices: $99.00, $419.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 342639-96-7
• Chemical Name: N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine
• Formula: C13H12N6O2
• Molecular Weight: 284.27
• Purity: >99 %
• Description: Heat shock factor (HSF) inhibitor (IC 50 = 1.2 μ M). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth in vivo .

Product References

KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 - KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1

Yoon YJ, Kim JA, Shin KD, Shin DS, Han YM, Lee YJ, Lee JS, Kwon BM, Han DC. J Biol Chem. 2011 Jan 21;286(3):1737-47.

Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 - Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1

Samarasinghe B, Wales CT, Taylor FR, Jacobs AT. Biochem Pharmacol. 2014 Feb 1;87(3):445-55.