KT 5720

• Supplier: Tocris Bioscience
• Catalog: 4169
• Prices: $185.00
• Sizes: 100 µg
• Function Type: Inhibitor
• Cas Number: 108068-98-0
• Chemical Name: (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacid,hexylester
• Formula: C32H31N3O5
• Molecular Weight: 537.61
• Purity: >98 %
• Description: Potent, selective inhibitor of protein kinase A (K i = 60 nM). Has no effect on PKG or PKC (K i > 2 μ M). Reversibly arrests human skin fibroblasts in the G 1 phase.

Product References

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic - K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic

Kase H, Iwahashi K, Nakanishi S, Matsuda Y, Yamada K, Takahashi M, Murakata C, Sato A, Kaneko M. Biochem Biophys Res Commun. 1987 Jan 30;142(2):436-40.

Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells - Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells

Gadbois DM, Crissman HA, Tobey RA, Bradbury EM. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30.

Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein - Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein

Cabell L, Audesirk G. Int J Dev Neurosci. 1993 Jun;11(3):357-68.