KT 5823

Name KT 5823
Supplier Tocris Bioscience
Catalog 1288
Prices $185.00
Sizes 100 µg
Function Type Inhibitor
Cas Number 126643-37-6
Chemical Name (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacid,methylester
Formula C29H25N3O5
Molecular Weight 495.53
Purity >98 %
Description Selective inhibitor of protein kinase G (K i values are 0.23, 4 and > 10 μ M for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC 50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μ M.
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Product References

Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells - Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells

Gadbois DM, Crissman HA, Tobey RA, Bradbury EM. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30.

Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed - Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed

Murthy KS, Makhlouf GM. Am J Physiol. 1995 Jan;268(1 Pt 1):C171-80.

Functional analysis of cGMP-dependent protein kinases I and II as mediators of - Functional analysis of cGMP-dependent protein kinases I and II as mediators of

Smolenski A, Burkhardt AM, Eigenthaler M, Butt E, Gambaryan S, Lohmann SM, Walter U. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jul;358(1):134-9.