| Name | KU 0060648 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1289 |
| Prices | $245.00, $1,005.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 881375-00-4 |
| Chemical Name | 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide |
| Formula | C33H34N4O4S |
| Molecular Weight | 582.71 |
| Purity | >97 % |
| Description | Dual PI 3-K and DNA-PK inhibitor (IC 50 values are <0.1, 0.5, 4 and 19 nM for PI 3-K δ , PI 3-K β , PI 3-K α and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency ~2 to 4-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%; maximum effect seen at 250 nM. |
| Supplier Page | Shop |
Dumont F, Altmeyer A, Bischoff P. Expert Opin Ther Pat. 2009 Jun;19(6):775-99.
Munck JM, Batey MA, Zhao Y, Jenkins H, Richardson CJ, Cano C, Tavecchio M, Barbeau J, Bardos J, Cornell L, Griffin RJ, Menear K, Slade A, Thommes P, Martin NM, Newell DR, Smith GC, Curtin NJ. Mol Cancer Ther. 2012 Aug;11(8):1789-98.