KU 55933

• Supplier: Tocris Bioscience
• Catalog: 3725
• Prices: $205.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 587871-26-9
• Chemical Name: 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
• Formula: C21H17NO3S2
• Molecular Weight: 395.49
• Purity: >98 %
• Description: Potent, selective and competitive ATM kinase inhibitor (K i = 2.2 nM, IC 50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer.

Product References

Identification and characterization of a novel and specific inhibitor of the - Identification and characterization of a novel and specific inhibitor of the

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Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and - Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and

Eaton JS, Lin ZP, Sartorelli AC, Bonawitz ND, Shadel GS. J Clin Invest. 2007 Sep;117(9):2723-34.

Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced - Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced

Crescenzi E, Palumbo G, de Boer J, Brady HJ. Clin Cancer Res. 2008 Mar 15;14(6):1877-87.