KYL

Name KYL
Supplier Tocris Bioscience
Catalog 4731
Prices $165.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 676657-00-4
Formula C74H108N14O17
Molecular Weight 1465.75
Description EphA4 receptor tyrosine kinase inhibitor (K d = 0.8 μ M); inhibits EphA4-EphrinA5 interactions (IC 50 = 6.34 μ M). Prevents A β O induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective.
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Product References

Distinctive binding of three antagonistic peptides to the ephrin-binding pocket - Distinctive binding of three antagonistic peptides to the ephrin-binding pocket

Lamberto I, Qin H, Noberini R, Premkumar L, Bourgin C, Riedl SJ, Song J, Pasquale EB. Biochem J. 2012 Jul 1;445(1):47-56.

EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by - EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by

Vargas LM, Leal N, Estrada LD, Gonzalez A, Serrano F, Araya K, Gysling K, Inestrosa NC, Pasquale EB, Alvarez AR. PLoS One. 2014 Mar 21;9(3):e92309.