L 760735

• Supplier: Tocris Bioscience
• Catalog: 5085
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 188923-01-5
• Chemical Name: 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl-N,N-dimethyl-1H-1,2,3-triazole-4-methanaminehydrochloride
• Formula: C26H28F7N5O2.HCl
• Molecular Weight: 611.98
• Purity: >99 %
• Description: High affinity NK 1 receptor antagonist (IC 50 = 0.19 nM at human NK 1 receptors). Selective (>300-fold) over h-NK 2 and h-NK 3 receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active.

Product References

An orally active, water-soluble neurokinin-1 receptor antagonist suitable for - An orally active, water-soluble neurokinin-1 receptor antagonist suitable for

Harrison T, Owens AP, Williams BJ, Swain CJ, Williams A, Carlson EJ, Rycroft W, Tattersall FD, Cascieri MA, Chicchi GG, Sadowski S, Rupniak NM, Hargreaves RJ. J Med Chem. 2001 Nov 22;44(24):4296-9.

Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with - Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with

Duffy RA, Varty GB, Morgan CA, Lachowicz JE. J Pharmacol Exp Ther. 2002 May;301(2):536-42.