L-152,804

• Supplier: Tocris Bioscience
• Catalog: 2444
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 6508-43-6
• Chemical Name: 5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione
• Formula: C23H26O4
• Molecular Weight: 366.46
• Purity: >99 %
• Description: Potent, selective non-peptide neuropeptide Y Y 5 receptor antagonist (K i = 26 nM for hY 5 ). Displays > 300-fold selectivity over hY 1 , hY 2 , and hY 4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo .

Product References

L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. - L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist.

Kanatani A, Ishihara A, Iwaasa H, Nakamura K, Okamoto O, Hidaka M, Ito J, Fukuroda T, MacNeil DJ, Van der Ploeg LH, Ishii Y, Okabe T, Fukami T, Ihara M. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73.

The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol - The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol

Schroeder JP, Overstreet DH, Hodge CW. Alcohol. 2005 Jul;36(3):179-86.

A pair-feeding study reveals that a Y5 antagonist causes weight loss in - A pair-feeding study reveals that a Y5 antagonist causes weight loss in

Mashiko S, Ishihara A, Iwaasa H, Sano H, Ito J, Gomori A, Oda Z, Moriya R, Matsushita H, Jitsuoka M, Okamoto O, MacNeil DJ, Van der Ploeg LH, Fukami T, Kanatani A. Mol Pharmacol. 2007 Feb;71(2):602-8. Epub 2006 Nov 14.