L-161,982

• Supplier: Tocris Bioscience
• Catalog: 1382
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 147776-06-5
• Chemical Name: N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide
• Formula: C32H29F3N4O4S2
• Molecular Weight: 654.72
• Purity: >99 %
• Description: EP 4 receptor antagonist that is selective over all other members of the prostanoid receptor family (K i values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μ M for human EP 4 , TP, EP 3 , DP, FP, IP, EP 1 and EP 2 receptors respectively). Suppresses PGE 2 -induced bone formation in rats and prevents the nociceptive response induced by misoprostol in formalin-injected mice.

Product References

Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2). - Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2).

Machwate M, Harada S, Leu CT, Seedor G, Labelle M, Gallant M, Hutchins S, Lachance N, Sawyer N, Slipetz D, Metters KM, Rodan SB, Young R, Rodan GA. Mol Pharmacol. 2001 Jul;60(1):36-41.

Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent - Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent

Balzary RW, Cocks TM. J Pharmacol Exp Ther. 2006 May;317(2):806-12. Epub 2006 Feb 7.

Role of periaqueductal grey prostaglandin receptors in formalin-induced - Role of periaqueductal grey prostaglandin receptors in formalin-induced

Oliva P, Berrino L, de Novellis V, Palazzo E, Marabese I, Siniscalco D, Scafuro M, Mariani L, Rossi F, Maione S. Eur J Pharmacol. 2006 Jan 13;530(1-2):40-7. Epub 2005 Dec 19.