L-165,041

• Supplier: Tocris Bioscience
• Catalog: 2514
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 79558-09-1
• Chemical Name: [4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]aceticacid
• Formula: C22H26O7
• Molecular Weight: 402.44
• Purity: >98 %
• Description: Potent PPAR δ agonist (K i = 6 nM); displays > 100-fold selectivity for both mouse and human PPAR δ receptors over other subtypes. Raises plasma cholesterol levels in vivo , in insulin-resistant db/db mice. Neuroprotective in models of cerebral infarction and Parkinson's disease.

Product References

Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta - Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta

Berger J, Leibowitz MD, Doebber TW, Elbrecht A, Zhang B, Zhou G, Biswas C, Cullinan CA, Hayes NS, Li Y, Tanen M, Ventre J, Wu MS, Berger GD, Mosley R, Marquis R, Santini C, Sahoo SP, Tolman RL, Smith RG, Moller DE. J Biol Chem. 1999 Mar 5;274(10):6718-25.

Activation of PPARdelta alters lipid metabolism in db/db mice. - Activation of PPARdelta alters lipid metabolism in db/db mice.

Leibowitz MD, Fievet C, Hennuyer N, Peinado-Onsurbe J, Duez H, Bergera J, Cullinan CA, Sparrow CP, Baffic J, Berger GD, Santini C, Marquis RW, Tolman RL, Smith RG, Moller DE, Auwerx J. FEBS Lett. 2000 May 19;473(3):333-6.

Neuroprotective efficacy of the peroxisome proliferator-activated receptor - Neuroprotective efficacy of the peroxisome proliferator-activated receptor

Iwashita A, Muramatsu Y, Yamazaki T, Muramoto M, Kita Y, Yamazaki S, Mihara K, Moriguchi A, Matsuoka N. J Pharmacol Exp Ther. 2007 Mar;320(3):1087-96. Epub 2006 Dec 13.