| Name | L189 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2311 |
| Prices | $159.00, $665.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 64232-83-3 |
| Chemical Name | 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone |
| Formula | C11H10N4OS |
| Molecular Weight | 246.29 |
| Description | DNA ligase I, III and IV inhibitor (IC 50 values are 5, 9 and 5 μ M respectively) that blocks DNA binding (K i = 5 μ M for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. |
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