L-365,260

Name L-365,260
Supplier Tocris Bioscience
Catalog 2660
Prices $225.00, $925.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 118101-09-0
Chemical Name N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea
Formula C24H22N4O2
Molecular Weight 398.46
Purity >99 %
Description Selective cholecystokinin receptor 2 (CCK 2 ) antagonist (IC 50 values are 2 and 280 nM at CCK 2 and CCK 1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α - and β adrenergic, histamine, angiotensin and bradykinin receptors.
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Product References

Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260. - Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.

Bock MG, DiPardo RM, Evans BE, Rittle KE, Whitter WL, Veber DE, Anderson PS, Freidinger RM. J Med Chem. 1989 Jan;32(1):13-6.

A new potent and selective non-peptide gastrin antagonist and brain - A new potent and selective non-peptide gastrin antagonist and brain

Lotti VJ, Chang RS. Eur J Pharmacol. 1989 Mar 21;162(2):273-80.

Cholecystokinin action on layer 6b neurons in somatosensory cortex. - Cholecystokinin action on layer 6b neurons in somatosensory cortex.

Chung L, Moore SD, Cox CL. Brain Res. 2009 Jul 28;1282:10-9.