L-368,899 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2767
• Prices: $135.00, $289.00
• Sizes: 1 mg, 10 mg
• Function Type: Antagonist
• Cas Number: 160312-62-9
• Chemical Name: (2S)-2-Amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)butanamide
• Formula: C26H42N4O5S2.HCl
• Molecular Weight: 591.23
• Purity: >97 %
• Description: Potent, non-peptide and orally active oxytocin receptor antagonist (IC 50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V 1a and V 2 receptors (IC 50 values are 370 and 570 nM respectively). Antagonizes oxytocin-induced uterine contractions in vitro and in vivo .

Product References

1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo - 1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo

Williams PD, Anderson PS, Ball RG, Bock MG, Carroll L, Chiu SH, Clineschmidt BV, Culberson JC, Erb JM, Evans BE, et al.. J Med Chem. 1994 Mar 4;37(5):565-71.

Attenuation of PGF2alpha release in ewes infused with the oxytocin antagonist - Attenuation of PGF2alpha release in ewes infused with the oxytocin antagonist

Mann GE, Lamming GE, Scholey D, Hunter M, Pettibone DJ. Domest Anim Endocrinol. 2003 Oct;25(3):255-62.

Discovery and development of a new class of potent, selective, orally active - Discovery and development of a new class of potent, selective, orally active

Quattropani A, Dorbais J, Covini D, Pittet PA, Colovray V, Thomas RJ, Coxhead R, Halazy S, Scheer A, Missotten M, Ayala G, Bradshaw C, De Raemy-Schenk AM, Nichols A, Cirillo R, Tos EG, Giachetti C, Golzio L, Marinelli P, Church DJ, Barberis C, Chollet A, Schwarz MK. J Med Chem. 2005 Dec 1;48(24):7882-905.

Oral oxytocin antagonists. - Oral oxytocin antagonists.

Borthwick AD. J Med Chem. 2010 Sep 23;53(18):6525-38.