L-371,257

• Supplier: Tocris Bioscience
• Catalog: 2641
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 162042-44-6
• Chemical Name: 1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine
• Formula: C28H33N3O6
• Molecular Weight: 507.59
• Purity: >99 %
• Description: Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active.

Product References

1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- - 1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4-

Williams PD, Clineschmidt BV, Erb JM, Freidinger RM, Guidotti MT, Lis EV, Pawluczyk JM, Pettibone DJ, Reiss DR, Veber DF, et al.. J Med Chem. 1995 Nov 10;38(23):4634-6.

Comparison of vasopressin binding sites in human uterine and vascular smooth - Comparison of vasopressin binding sites in human uterine and vascular smooth

Tahara A, Tsukada J, Ishii N, Tomura Y, Wada K, Kusayama T, Yatsu T, Uchida W, Tanaka A. Eur J Pharmacol. 1999 Jul 28;378(1):137-42.

Pharmacologic characterization of the oxytocin receptor in human uterine smooth - Pharmacologic characterization of the oxytocin receptor in human uterine smooth

Tahara A, Tsukada J, Tomura Y, Wada Ki, Kusayama T, Ishii N, Yatsu T, Uchida W, Tanaka A. Br J Pharmacol. 2000 Jan;129(1):131-9.