L-670,596

• Supplier: Tocris Bioscience
• Catalog: 1327
• Prices: $189.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 121083-05-4
• Chemical Name: (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-aceticacid
• Formula: C22H21F2NO4S
• Molecular Weight: 433.47
• Purity: >98 %
• Description: Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist (IC 50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA 2 = 9.0) and human platelet aggregation in vitro (IC 50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo .

Product References

The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin - The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin

Ford-Hutchinson AW, Girard Y, Lord A, Jones TR, Cirino M, Evans JF, Gillard J, Hamel P, Leveille C, Masson P, et al.. Can J Physiol Pharmacol. 1989 Sep;67(9):989-93.

Tetrahydrocarbazol-1-acetic acids: new class of thromboxane receptor antagonists. - Tetrahydrocarbazol-1-acetic acids: new class of thromboxane receptor antagonists.

Girard Y, Yoakim-Rancourt C, Hamel P, Gillard JW, Guindon Y, Letts G, Evans J, Leveille C, Ethier D, Lord A, et al.. Prog Clin Biol Res. 1989;301:585-9.

Role of thromboxane in retinal microvascular degeneration in oxygen-induced - Role of thromboxane in retinal microvascular degeneration in oxygen-induced

Beauchamp MH, Martinez-Bermudez AK, Gobeil F Jr, Marrache AM, Hou X, Speranza G, Abran D, Quiniou C, Lachapelle P, Roberts J 2nd, Almazan G, Varma DR, Chemtob S. J Appl Physiol (1985). 2001 Jun;90(6):2279-88.