L-690,330

Name L-690,330
Supplier Tocris Bioscience
Catalog 0682
Prices $159.00, $665.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 142523-38-4
Chemical Name [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonicacid
Formula C8H12O8P2
Molecular Weight 298.13
Description A potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.
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Product References

In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate - In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate

Atack JR, Cook SM, Watt AP, Fletcher SR, Ragan CI. J Neurochem. 1993 Feb;60(2):652-8.

Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase - Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase

Atack JR, Prior AM, Fletcher SR, Quirk K, McKernan R, Ragan CI. J Pharmacol Exp Ther. 1994 Jul;270(1):70-6.

Lithium induces autophagy by inhibiting inositol monophosphatase. - Lithium induces autophagy by inhibiting inositol monophosphatase.

Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC. J Cell Biol. 2005 Sep 26;170(7):1101-11.

Chemical modulators of autophagy as biological probes and potential therapeutics. - Chemical modulators of autophagy as biological probes and potential therapeutics.

Fleming A, Noda T, Yoshimori T, Rubinsztein DC. Nat Chem Biol. 2011 Jan;7(1):9-17.