L-732,138

• Supplier: Tocris Bioscience
• Catalog: 2640
• Prices: $89.00, $345.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 148451-96-1
• Chemical Name: N-Acetyl-L-tryptophan3,5-bis(trifluoromethyl)benzylester
• Formula: C22H18F6N2O3
• Molecular Weight: 472.39
• Purity: >98 %
• Description: Potent and highly selective competitive tachykinin NK 1 receptor antagonist (IC 50 = 2.3 nM).

Product References

N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists. - N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists.

MacLeod AM, Merchant KJ, Cascieri MA, Sadowski S, Ber E, Swain CJ, Baker R. J Med Chem. 1993 Jul 9;36(14):2044-5.

Characterization of the interaction of N-acyl-L-tryptophan benzyl ester - Characterization of the interaction of N-acyl-L-tryptophan benzyl ester

Cascieri MA, Macleod AM, Underwood D, Shiao LL, Ber E, Sadowski S, Yu H, Merchant KJ, Swain CJ, Strader CD, et al.. J Biol Chem. 1994 Mar 4;269(9):6587-91.

Identification of L-tryptophan derivatives with potent and selective antagonist - Identification of L-tryptophan derivatives with potent and selective antagonist

MacLeod AM, Merchant KJ, Brookfield F, Kelleher F, Stevenson G, Owens AP, Swain CJ, Casiceri MA, Sadowski S, Ber E, et al.. J Med Chem. 1994 Apr 29;37(9):1269-74.

Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways. - Lipopolysaccharide enhances neurogenic plasma exudation in guinea-pig airways.

Kuo HP, Hwang KH, Lin HC, Wang CH, Liu CY, Lu LC. Br J Pharmacol. 1998 Oct;125(4):711-6.