L-741,626

• Supplier: Tocris Bioscience
• Catalog: 1004
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 81226-60-0
• Chemical Name: 3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
• Formula: C20H21ClN2O
• Molecular Weight: 340.85
• Purity: >98 %
• Description: A potent D 2 dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D 2 , D 3 and D 4 receptors respectively. Centrally active following systemic administration in vivo .

Product References

Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat - Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat

Bowery BJ, Razzaque Z, Emms F, Patel S, Freedman S, Bristow L, Kulagowski J, Seabrook GR. Br J Pharmacol. 1996 Dec;119(7):1491-7.

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an - 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an

Kulagowski JJ, Broughton HB, Curtis NR, Mawer IM, Ridgill MP, Baker R, Emms F, Freedman SB, Marwood R, Patel S, Patel S, Ragan CI, Leeson PD. J Med Chem. 1996 May 10;39(10):1941-2.

Human D2 and D4 dopamine receptors couple through betagamma G-protein subunits to - Human D2 and D4 dopamine receptors couple through betagamma G-protein subunits to

Pillai G, Brown NA, McAllister G, Milligan G, Seabrook GR. Neuropharmacology. 1998 Aug;37(8):983-7.

S33084, a novel, potent, selective, and competitive antagonist at dopamine - S33084, a novel, potent, selective, and competitive antagonist at dopamine

Millan MJ, Dekeyne A, Rivet JM, Dubuffet T, Lavielle G, Brocco M. J Pharmacol Exp Ther. 2000 Jun;293(3):1063-73.