L-745,870 trihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1003
• Prices: $139.00, $579.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 866021-03-6
• Chemical Name: 3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridinetrihydrochloride
• Formula: C18H19N4Cl.3HCl
• Molecular Weight: 436.21
• Purity: >99 %
• Description: A highly potent and selective D 4 dopamine receptor antagonist; L-745,870 has K i values of 0.51, 2300 and 960 nM for D 4 , D 3 and D 2 subtypes respectively and > 1000-fold selectivity over 5-HT 2 , D 1 and D 5 receptors.

Product References

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an - 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an

Kulagowski JJ, Broughton HB, Curtis NR, Mawer IM, Ridgill MP, Baker R, Emms F, Freedman SB, Marwood R, Patel S, Patel S, Ragan CI, Leeson PD. J Med Chem. 1996 May 10;39(10):1941-2.

Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist. - Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist.

Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR. Trends Pharmacol Sci. 1997 Jun;18(6):186-8.

Biological profile of L-745,870, a selective antagonist with high affinity for - Biological profile of L-745,870, a selective antagonist with high affinity for

Patel S, Freedman S, Chapman KL, Emms F, Fletcher AE, Knowles M, Marwood R, Mcallister G, Myers J, Curtis N, Kulagowski JJ, Leeson PD, Ridgill M, Graham M, Matheson S, Rathbone D, Watt AP, Bristow LJ, Rupniak NM, Baskin E, Lynch JJ, Ragan CI. J Pharmacol Exp Ther. 1997 Nov;283(2):636-47.

Human D2 and D4 dopamine receptors couple through betagamma G-protein subunits to - Human D2 and D4 dopamine receptors couple through betagamma G-protein subunits to

Pillai G, Brown NA, McAllister G, Milligan G, Seabrook GR. Neuropharmacology. 1998 Aug;37(8):983-7.