L-838,417

• Supplier: Tocris Bioscience
• Catalog: 1980
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 286456-42-6
• Chemical Name: 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
• Formula: C19H19F2N7O
• Molecular Weight: 399.4
• Purity: >98 %
• Description: Subtype-selective GABA A receptor partial agonist. Selectively binds to α 1, α 2, α 3 and α 5 subunits (K i values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α 1 ( α 1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo .

Product References

Subtype-selective GABAergic drugs facilitate extinction of mouse operant - Subtype-selective GABAergic drugs facilitate extinction of mouse operant

McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, Reynolds DS, Leslie JC. Neuropharmacology. 2004 Feb;46(2):171-8.

Differential behavioral effects of low efficacy positive GABAA modulators in - Differential behavioral effects of low efficacy positive GABAA modulators in

McMahon LR, France CP. Br J Pharmacol. 2006 Feb;147(3):260-8.

Reversal of pathological pain through specific spinal GABAA receptor subtypes. - Reversal of pathological pain through specific spinal GABAA receptor subtypes.

Knabl J, Witschi R, Hosl K, Reinold H, Zeilhofer UB, Ahmadi S, Brockhaus J, Sergejeva M, Hess A, Brune K, Fritschy JM, Rudolph U, Mohler H, Zeilhofer HU. Nature. 2008 Jan 17;451(7176):330-4.