Lactacystin

• Supplier: Tocris Bioscience
• Catalog: 3250
• Prices: $289.00
• Sizes: 200 µg
• Function Type: Inhibitor
• Cas Number: 133343-34-7
• Chemical Name: (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteinethioester
• Formula: C15H24N2O7S
• Molecular Weight: 376.42
• Description: A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF- κ B activation (IC 50 = 10 μ M).

Product References

Lactacystin, a novel microbial metabolite, induces neuritogenesis of - Lactacystin, a novel microbial metabolite, induces neuritogenesis of

Omura S, Fujimoto T, Otoguro K, Matsuzaki K, Moriguchi R, Tanaka H, Sasaki Y. J Antibiot (Tokyo). 1991 Jan;44(1):113-6.

Inhibition of proteasome activities and subunit-specific amino-terminal threonine - Inhibition of proteasome activities and subunit-specific amino-terminal threonine

Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL. Science. 1995 May 5;268(5211):726-31.

Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes. - Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes.

Bellas RE, FitzGerald MJ, Fausto N, Sonenshein GE. Am J Pathol. 1997 Oct;151(4):891-6.