Lamotrigine

• Supplier: Tocris Bioscience
• Catalog: 2267
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Cas Number: 84057-84-1
• Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
• Formula: C9H7Cl2N5
• Molecular Weight: 256.09
• Purity: >99 %
• Description: Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na + , K + and Ca 2+ currents. Also blocks heterologously expressed and native α 4 β 2 nAChRs with a similar affinity to Na + channels. Water-soluble salt available ( lamotrigine isethionate , Cat. No. 2289).

Product References

Neurochemical and behavioral aspects of lamotrigine. - Neurochemical and behavioral aspects of lamotrigine.

Leach MJ, Baxter MG, Critchley MA. Epilepsia. 1991;32 Suppl 2:S4-8.

Lamotrigine reduces voltage-gated sodium currents in rat central neurons in - Lamotrigine reduces voltage-gated sodium currents in rat central neurons in

Zona C, Avoli M. Epilepsia. 1997 May;38(5):522-5.

Modulation of calcium and potassium currents by lamotrigine. - Modulation of calcium and potassium currents by lamotrigine.

Grunze H, von Wegerer J, Greene RW, Walden J. Neuropsychobiology. 1998 Oct;38(3):131-8.

The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic - The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic

Zheng C, Yang K, Liu Q, Wang MY, Shen J, Valles AS, Lukas RJ, Barrantes FJ, Wu J. J Pharmacol Exp Ther. 2010 Nov;335(2):401-8.