Lansoprazole

• Supplier: Tocris Bioscience
• Catalog: 2289
• Prices: $65.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 103577-45-3
• Chemical Name: 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
• Formula: C16H14F3N3O2S
• Molecular Weight: 369.36
• Purity: >99 %
• Description: H + ,K + -ATPase inhibitor (IC 50 = 6.3 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.09 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro . Also blocks swelling-dependent chloride channel (ICIswell) in NIH3T3 fibroblasts. More potent than omeprazole (Cat. No. 2583).

Product References

Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 - Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749

Satoh H, Inatomi N, Nagaya H, Inada I, Nohara A, Nakamura N, Maki Y. J Pharmacol Exp Ther. 1989 Feb;248(2):806-15.

The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. - The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels.

Schmarda A, Dinkhauser P, Gschwentner M, Ritter M, Furst J, Scandella E, Woll E, Laich A, Rossmann H, Seidler U, Lang F, Paulmichl M. Br J Pharmacol. 2000 Feb;129(3):598-604.

Lansoprazole: an update of its place in the management of acid-related disorders. - Lansoprazole: an update of its place in the management of acid-related disorders.

Matheson AJ, Jarvis B. Drugs. 2001;61(12):1801-33.