Lavendustin A

Name Lavendustin A
Supplier Tocris Bioscience
Catalog 4422
Prices $175.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 125697-92-9
Chemical Name 5-[[(2,5-Dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoicacid
Formula C21H19NO6
Molecular Weight 381.38
Purity >98 %
Description Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 11 nM). Inhibits p60 c-src with an IC 50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC 50 > 100 μ M).
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Product References

Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces - Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces

Onoda T, Iinuma H, Sasaki Y, Hamada M, Isshiki K, Naganawa H, Takeuchi T, Tatsuta K, Umezawa K. J Nat Prod. 1989 Nov-Dec;52(6):1252-7.

Kinetic analysis of the inhibition of the epidermal growth factor receptor - Kinetic analysis of the inhibition of the epidermal growth factor receptor

Hsu CY, Persons PE, Spada AP, Bednar RA, Levitzki A, Zilberstein A. J Biol Chem. 1991 Nov 5;266(31):21105-12.

Long-term potentiation in the hippocampus is blocked by tyrosine kinase - Long-term potentiation in the hippocampus is blocked by tyrosine kinase

O'Dell TJ, Kandel ER, Grant SG. Nature. 1991 Oct 10;353(6344):558-60.