LB 42708

• Supplier: Tocris Bioscience
• Catalog: 2460
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 226929-39-1
• Chemical Name: [1-[[1-[(4-Bromophenyl)methyl]-1H-imidazol-5-yl]methyl]-4-(1-naphthalenyl)-1H-pyrrol-3-yl]-4-morpholinylmethanone
• Formula: C30H27BrN4O2
• Molecular Weight: 555.46
• Purity: >98 %
• Description: Selective inhibitor of farnesyltransferase (FTase). Blocks farnesylation of H-Ras, N-Ras and K-Ras4B (IC 50 values are 0.8, 1.2 and 2.0 nM respectively). Displays >50,000-fold selectivity for FTase over geranylgeranyltransferase (GGTase) I. Inhibits VEGF-induced Ras activation; suppresses angiogenesis in vivo and in vitro (IC 50 = 75 nM). Orally active.

Product References

Inhibition of farnesyltransferase prevents collagen-induced arthritis by - Inhibition of farnesyltransferase prevents collagen-induced arthritis by

Na HJ, Lee SJ, Kang YC, Cho YL, Nam WD, Kim PK, Ha KS, Chung HT, Lee H, Kwon YG, Koh JS, Kim YM. J Immunol. 2004 Jul 15;173(2):1276-83.

The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth - The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth

Kim CK, Choi YK, Lee H, Ha KS, Won MH, Kwon YG, Kim YM. Mol Pharmacol. 2010 Jul;78(1):142-50.