LDN 27219

• Supplier: Tocris Bioscience
• Catalog: 5082
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 312946-37-5
• Chemical Name: 2-[(3,4-Dihydro-4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)thio]aceticacidhydrazide
• Formula: C20H16N4O2S2
• Molecular Weight: 408.5
• Purity: >99 %
• Description: Transglutaminase 2 (TG2) inhibitor (IC 50 = 0.25 μ M). Binds at GTPase site; reversible.

Product References

Structure-activity relationship study of novel tissue transglutaminase - Structure-activity relationship study of novel tissue transglutaminase

Duval E, Case A, Stein RL, Cuny GD. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1885-9.

Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic - Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic

Case A, Stein RL. Biochemistry. 2007 Jan 30;46(4):1106-15.

Discovery and structure-activity relationship of potent and selective covalent - Discovery and structure-activity relationship of potent and selective covalent

Prime ME, Andersen OA, Barker JJ, Brooks MA, Cheng RK, Toogood-Johnson I, Courtney SM, Brookfield FA, Yarnold CJ, Marston RW, Johnson PD, Johnsen SF, Palfrey JJ, Vaidya D, Erfan S, Ichihara O, Felicetti B, Palan S, Pedret-Dunn A, Schaertl S, Sternberger I, Ebneth A, Scheel A, Winkler D, Toledo-Sherman L, Beconi M, Macdonald D, Munoz-Sanjuan I, Dominguez C, Wityak J. J Med Chem. 2012 Feb 9;55(3):1021-46.