LDN 57444

• Supplier: Tocris Bioscience
• Catalog: 4602
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 668467-91-2
• Chemical Name: 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione3-(O-acetyloxime)
• Formula: C17H11Cl3N2O3
• Molecular Weight: 397.64
• Purity: >98 %
• Description: Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (K i = 0.4 μ M). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo .

Product References

Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 - Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299

Liu Y, Lashuel HA, Choi S, Xing X, Case A, Ni J, Yeh LA, Cuny GD, Stein RL, Lansbury PT Jr. Chem Biol. 2003 Sep;10(9):837-46.

Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 - Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1

Tan YY, Zhou HY, Wang ZQ, Chen SD. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.

Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. - Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.

Cartier AE, Djakovic SN, Salehi A, Wilson SM, Masliah E, Patrick GN. J Neurosci. 2009 Jun 17;29(24):7857-68.