LE 300

• Supplier: Tocris Bioscience
• Catalog: 2021
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 274694-98-3
• Chemical Name: 6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f][3]benzazecine
• Formula: C20H22N2
• Molecular Weight: 290.41
• Purity: >98 %
• Description: Potent and selective dopamine D 1 receptor antagonist (K i values are 0.08 - 1.9 nM and 6 - 45 nM for D 1 and D 2 receptors respectively). Also displays moderate affinity for the 5-HT 2A receptor (K i = 20 nM). Active in vivo .

Product References

7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new - 7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new

Witt T, Hock FJ, Lehmann J. J Med Chem. 2000 May 18;43(10):2079-81.

Dopamine/serotonin receptor ligands. Part IV [1]: synthesis and pharmacology of - Dopamine/serotonin receptor ligands. Part IV [1]: synthesis and pharmacology of

El-Subbagh H, Wittig T, Decker M, Elz S, Nieger M, Lehmann J. Arch Pharm (Weinheim). 2002 Nov;335(9):443-8.

Pharmacological characterization of the benz[d]indolo[2,3-g]azecine LE300, a - Pharmacological characterization of the benz[d]indolo[2,3-g]azecine LE300, a

Kassack MU, Hofgen B, Decker M, Eckstein N, Lehmann J. Naunyn Schmiedebergs Arch Pharmacol. 2002 Dec;366(6):543-50. Epub 2002 Oct 11.