Leflunomide

• Supplier: Tocris Bioscience
• Catalog: 2139
• Prices: $95.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 75706-12-6
• Chemical Name: 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
• Formula: C12H9F3N2O2
• Molecular Weight: 270.21
• Purity: >99 %
• Description: Inhibitor of dihydroorotate dehydrogenase (IC 50 = 2.5 μ M). Inhibits de novo pyrimidine synthesis in human T cells in vitro ; also inhibits lymphocyte proliferation. Exhibits efficacy in several animal models of autoimmune disease, arthritis and graft rejection. Active metabolite, teriflunomide (A77 1726, Cat. No. 5069), also available.

Product References

The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting - The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting

Cherwinski HM, Cohn RG, Cheung P, Webster DJ, Xu YZ, Caulfield JP, Young JM, Nakano G, Ransom JT. J Pharmacol Exp Ther. 1995 Nov;275(2):1043-9.

Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent - Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent

Greene S, Watanabe K, Braatz-Trulson J, Lou L. Biochem Pharmacol. 1995 Sep 7;50(6):861-7.

Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: - Molecular mechanisms of action of new xenobiotic immunosuppressive drugs:

Brazelton TR, Morris RE. Curr Opin Immunol. 1996 Oct;8(5):710-20.