Leptomycin B

Name Leptomycin B
Supplier Tocris Bioscience
Catalog 2985
Prices $329.00
Sizes 5 µg
Function Type Inhibitor
Cas Number 87081-35-4
Chemical Name (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoicacid
Formula C33H48O6
Molecular Weight 540.74
Description Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo .
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Product References

In vivo and in vitro anticancer activity of the structurally novel and highly - In vivo and in vitro anticancer activity of the structurally novel and highly

Roberts BJ, Hamelehle KL, Sebolt JS, Leopold WR. Cancer Chemother Pharmacol. 1986;16(2):95-101.

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic - Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic

Wolff B, Sanglier JJ, Wang Y. Chem Biol. 1997 Feb;4(2):139-47.

Nuclear export is required for degradation of endogenous p53 by MDM2 and human - Nuclear export is required for degradation of endogenous p53 by MDM2 and human

Freedman DA, Levine AJ. Mol Cell Biol. 1998 Dec;18(12):7288-93.

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to - Leptomycin B inhibition of signal-mediated nuclear export by direct binding to

Kudo N, Wolff B, Sekimoto T, Schreiner EP, Yoneda Y, Yanagida M, Horinouchi S, Yoshida M. Exp Cell Res. 1998 Aug 1;242(2):540-7.