Letrozole

Name Letrozole
Supplier Tocris Bioscience
Catalog 3395
Prices $69.00, $245.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 112809-51-5
Chemical Name 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
Formula C17H11N5
Molecular Weight 285.3
Purity >99 %
Description Potent, reversible non-steroidal aromatase inhibitor (IC 50 = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.
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Product References

Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new - Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new

Bhatnagar AS, Hausler A, Schieweck K, Lang M, Bowman R. J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):1021-7.

Letrozole as a potent inhibitor of cell proliferation and expression of - Letrozole as a potent inhibitor of cell proliferation and expression of

Mitropoulou TN, Tzanakakis GN, Kletsas D, Kalofonos HP, Karamanos NK. Int J Cancer. 2003 Mar 20;104(2):155-60.

The discovery and mechanism of action of letrozole. - The discovery and mechanism of action of letrozole.

Bhatnagar AS. Breast Cancer Res Treat. 2007;105 Suppl 1:7-17. Epub 2007 Oct 3.