Leukadherin 1

• Supplier: Tocris Bioscience
• Catalog: 4382
• Prices: $109.00, $459.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 344897-95-6
• Chemical Name: 4-[(5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoicacid
• Formula: C22H15NO4S2
• Molecular Weight: 421.49
• Purity: >98 %
• Description: Allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC 50 = 4 μ M). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.

Product References

Small molecule-mediated activation of the integrin CD11b/CD18 reduces - Small molecule-mediated activation of the integrin CD11b/CD18 reduces

Maiguel D, Faridi MH, Wei C, Kuwano Y, Balla KM, Hernandez D, Barth CJ, Lugo G, Donnelly M, Nayer A, Moita LF, Schurer S, Traver D, Ruiz P, Vazquez-Padron RI, Ley K, Reiser J, Gupta V. Sci Signal. 2011 Sep 6;4(189):ra57.

Complement receptor 3 influences toll-like receptor 7/8-dependent inflammation: - Complement receptor 3 influences toll-like receptor 7/8-dependent inflammation:

Reed JH, Jain M, Lee K, Kandimalla ER, Faridi MH, Buyon JP, Gupta V, Clancy RM. J Biol Chem. 2013 Mar 29;288(13):9077-83.