Levcromakalim

• Supplier: Tocris Bioscience
• Catalog: 2873
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Cas Number: 94535-50-9
• Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
• Formula: C16H18N2O3
• Molecular Weight: 286.33
• Purity: >99 %
• Description: Active enantiomer of the prototypical K ir 6 (K ATP ) channel opener cromakalim (Cat. No. 1377). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea.

Product References

Synthesis and smooth muscle relaxant activity of a new series of potassium - Synthesis and smooth muscle relaxant activity of a new series of potassium

Buckle DR, Arch JR, Edge C, Foster KA, Houge-Frydrych CS, Pinto IL, Smith DG, Taylor JF, Taylor SG, Tedder JM, et al.. J Med Chem. 1991 Mar;34(3):919-26.

Potassium channel modulation in rat portal vein by ATP depletion: a comparison - Potassium channel modulation in rat portal vein by ATP depletion: a comparison

Noack T, Edwards G, Deitmer P, Weston AH. Br J Pharmacol. 1992 Dec;107(4):945-55.

The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against - The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against

Taylor SG, Arch JR, Bond J, Buckle DR, Shaw DJ, Taylor JF, Ward JS. J Pharmacol Exp Ther. 1992 May;261(2):429-37.