LFM-A13

• Supplier: Tocris Bioscience
• Catalog: 4421
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 62004-35-7
• Chemical Name: 2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide
• Formula: C11H8Br2N2O2
• Molecular Weight: 360
• Purity: >98 %
• Description: Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC 50 value of 2.5 μ M and has no activity on other protein kinases ( including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations of up to 278 μ M.

Product References

Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's - Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's

Mahajan S, Ghosh S, Sudbeck EA, Zheng Y, Downs S, Hupke M, Uckun FM. J Biol Chem. 1999 Apr 2;274(14):9587-99.

Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling - Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling

Vassilev A, Ozer Z, Navara C, Mahajan S, Uckun FM. J Biol Chem. 1999 Jan 15;274(3):1646-56.

Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. - Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets.

Crosby D, Poole AW. J Biol Chem. 2002 Mar 22;277(12):9958-65. Epub 2002 Jan 11.