LG 100754

• Supplier: Tocris Bioscience
• Catalog: 1300
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 180713-37-5
• Chemical Name: (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid
• Formula: C26H36O3
• Molecular Weight: 396.56
• Purity: >99 %
• Description: Novel RXR:PPAR γ agonist; sensitizes PPAR γ by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPAR α heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXR α and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo .

Product References

The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose - The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose

Cesario RM, Klausing K, Razzaghi H, Crombie D, Rungta D, Heyman RA, Lala DS. Mol Endocrinol. 2001 Aug;15(8):1360-9.

The antidiabetic agent LG100754 sensitizes cells to low concentrations of - The antidiabetic agent LG100754 sensitizes cells to low concentrations of

Forman BM. J Biol Chem. 2002 Apr 12;277(15):12503-6. Epub 2002 Feb 27.

International Union of Pharmacology. LXIII. Retinoid X receptors. - International Union of Pharmacology. LXIII. Retinoid X receptors.

Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. Pharmacol Rev. 2006 Dec;58(4):760-72.

The "Phantom Effect" of the Rexinoid LG100754: structural and functional - The "Phantom Effect" of the Rexinoid LG100754: structural and functional

Sato Y, Ramalanjaona N, Huet T, Potier N, Osz J, Antony P, Peluso-Iltis C, Poussin-Courmontagne P, Ennifar E, Mely Y, Dejaegere A, Moras D, Rochel N. PLoS One. 2010 Nov 30;5(11):e15119.