Liarozole dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4896
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Chemical Name: 5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazoledihydrochloride
• Formula: C17H13ClN4.2HCl
• Molecular Weight: 381.69
• Purity: >99 %
• Description: Cytochrome P450 inhibitor. Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Blocks retinoic acid metabolism (retinoic acid metabolism blocking agent, RAMBA). Displays antitumor activity against androgen-dependent and independent rat prostate carcinomas.

Product References

Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic - Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic

Van Wauwe J, Van Nyen G, Coene MC, Stoppie P, Cools W, Goossens J, Borghgraef P, Janssen PA. J Pharmacol Exp Ther. 1992 May;261(2):773-9.

Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and - Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and

Njar VC, Gediya L, Purushottamachar P, Chopra P, Vasaitis TS, Khandelwal A, Mehta J, Huynh C, Belosay A, Patel J. Bioorg Med Chem. 2006 Jul 1;14(13):4323-40. Epub 2006 Mar 10.

Effects of liarozole fumarate (R85246) in combination with tamoxifen on - Effects of liarozole fumarate (R85246) in combination with tamoxifen on

Goss PE, Strasser-Weippl K, Qi S, Hu H. BMC Cancer. 2007 Jan 31;7:26.