Linopirdine dihydrochloride

Name Linopirdine dihydrochloride
Supplier Tocris Bioscience
Catalog 1461
Prices $175.00, $709.00
Sizes 10 mg, 50 mg
Function Type Blocker
Cas Number 113168-57-3
Chemical Name 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-onedihydrochloride
Formula C26H21N3O.2HCl
Molecular Weight 464.39
Purity >99 %
Description Blocker of K V 7 (KCNQ) voltage-gated potassium channels; blocks K V 7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC 50 = 4 - 7 μ M) and K V 7.1 (KCNQ1) homomeric channels (IC 50 = 8.9 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo .
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Product References

Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in - Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in

Schnee ME, Brown BS. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17.

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the - KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the

Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D. Science. 1998 Dec 4;282(5395):1890-3.

Two new potent neurotransmitter release enhancers, - Two new potent neurotransmitter release enhancers,

Zaczek R, Chorvat RJ, Saye JA, Pierdomenico ME, Maciag CM, Logue AR, Fisher BN, Rominger DH, Earl RA. J Pharmacol Exp Ther. 1998 May;285(2):724-30.