| Name | LLY 507 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5213 |
| Prices | $225.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 1793053-37-8 |
| Chemical Name | 3-Cyano-5-[2-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl]phenyl]-N-[3-(pyrrolidin-1-yl)propyl]benzamide |
| Formula | C36H42N6O |
| Molecular Weight | 574.76 |
| Purity | >98 % |
| Description | Potent SMYD2 inhibitor (IC 50 = 15 nM). Exhibits >100-fold selectivity for SMYD2 over 25 other methyltransferases including SMYD3, SUV420H1 and SUV420H2. Inhibits SMYD2-mediated p53 methylation in vitro . Also inhibits proliferation of a range of esophageal, liver and breast cancer cell lines. |
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Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM. J Clin Invest. 2010 May;120(5):1774-85.
Schmid DA, Yang T, Ogier M, Adams I, Mirakhur Y, Wang Q, Massa SM, Longo FM, Katz DM. J Neurosci. 2012 Feb 1;32(5):1803-10.