LM11A 31 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4607
• Prices: $105.00, $445.00
• Sizes: 10 mg, 50 mg
• Cas Number: 1243259-19-9
• Chemical Name: (2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamidedihydrochloride
• Formula: C12H25N3O2.2HCl
• Molecular Weight: 316.27
• Purity: >98 %
• Description: Nonpeptide p75 NTR ligand; blocks p75-mediated cell death and also increases proliferation and survival of hippocampal neural progenitors. Exhibits no effect on nerve growth factor (NGF) binding to TrkA. Prevents and reverses atrophy of cholinergic neurites, as well as reversing Alzheimer's Disease (AD) pathologies in mid- to late-stage AD mice models. Shown to promote functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.

Product References

The relationship of lecture attendance and course grade for second-year medical - The relationship of lecture attendance and course grade for second-year medical

Flournoy DJ, Hyde RM. J Okla State Med Assoc. 1984 Jan;77(1):20-2.

A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain - A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain

Shi J, Longo FM, Massa SM. Stem Cells. 2013 Nov;31(11):2561-74.

Oral administration of a small molecule targeted to block proNGF binding to p75 - Oral administration of a small molecule targeted to block proNGF binding to p75

Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO. J Neurosci. 2013 Jan 9;33(2):397-410.

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy - A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy

Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM. PLoS One. 2014 Aug 25;9(8):e102136.